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Secretin family of 7 transmembrane receptors is a family of evolutionarily related proteins. This family is known as Family B, the secretin-receptor family or family 2 of the G-protein-coupled receptors (GPCR). Many secretin receptors are regulated by peptide hormones from the glucagon hormone family. The secretin-receptor family GPCRs include vasoactive intestinal peptide receptors and receptors for secretin, calcitonin and parathyroid hormone/parathyroid hormone-related peptides. These receptors activate adenylyl cyclase and the phosphatidyl-inositol-calcium pathway. The receptors in this family have 7 transmembrane helices,〔; 〕 like rhodopsin-like GPCRs. However, there is no significant sequence identity between these two GPCR families and the secretin-receptor family has its own characteristic 7TM signature. The secretin-receptor family GPCRs exist in many animal species, but have not been found in plants, fungi or prokaryotes. Three distinct sub-families (B1-B3) are recognized. == Subfamily B1 == Subfamily B1 contains classical hormone receptors, such as receptors for secretin and glucagon, that are all involved in cAMP-mediated signalling pathways. * Pituitary adenylate cyclase-activating polypeptide type 1 receptor * * PACAPR (ADCYAP1R1) * Calcitonin receptor * * CALCR * Corticotropin-releasing hormone receptor * * CRHR1; CRHR2 * Glucose-dependent insulinotropic polypeptide receptor/Gastric inhibitory polypeptide receptor * * GIPR * Glucagon receptor * * GCGR * Glucagon receptor-related * * GLP1R; GLP2R; * Growth hormone releasing hormone receptor * * GHRHR * Parathyroid hormone receptor * * PTHR1; PTHR2 * Secretin receptor * * SCTR * Vasoactive intestinal peptide receptor * * VIPR1; VIPR2 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「secretin receptor family」の詳細全文を読む スポンサード リンク
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